英文名稱 | Sorafenib Tosylate |
---|---|
中文名稱 | 甲苯磺酸索拉非尼 |
CAS號 | 475207-59-1 |
分子式 | C28H24ClF3N4O6S |
分子量 | 637.03 |
外觀 | White to off-white powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Sorafenib Tosylate |
---|---|
中文名稱 | 甲苯磺酸索拉非尼 |
CAS號 | 475207-59-1 |
分子式 | C28H24ClF3N4O6S |
分子量 | 637.03 |
外觀 | White to off-white powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Sorafenib tosylate is a multikinase inhibitor of Raf-1 and B-Raf with IC50 of 6 nM and 22 nM in cell-free assays, respectively. Sorafenib Tosylate inhibits VEGFR-2, VEGFR-3, PDGFR-β, Flt-3 and c-KIT with IC50 of 90 nM, 20 nM, 57 nM, 59 nM and 68 nM, respectively. Sorafenib Tosylate induces autophagy and apoptosis and activates ferroptosis with anti-tumor activity.