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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
250 mg	In-stock	￥300.00	登錄后可見	- +
1 g	In-stock	￥850.00	登錄后可見	- +

規(guī)格

庫存

目錄價

會員專享價

數(shù)量

250 mg

In-stock

￥300.00

登錄后可見

- +

1 g

In-stock

￥850.00

登錄后可見

- +

基本信息

英文名稱	Osimertinib \| Mereletinib \| AZD-9291
中文名稱	奧希替尼 \| 邁瑞替尼
CAS號	1421373-65-0
分子式	C28H33N7O2
分子量	499.62
外觀	Off-white powder
儲存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

Osimertinib, also known as AZD-9291 and Mereletinib, is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. It inhibits both activating and resistant EGFR mutations while sparing the normal form of EGFR that is present in normal skin and gut cells, thereby reducing the side effects encountered with currently available medicines. Osimertinib was approved in Nov. 2015 by FDA.

相關(guān)文獻(xiàn)

AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer.

PMID: 24893891 PMCID: PMC4315625 DOI: 10.1158/2159-8290.CD-14-0337

PMID: 29467275 DOI: 10.1158/1535-7163.MCT-17-1033

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