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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
5 mg	3-5days	￥898.00	登錄后可見	- +
10 mg	3-5days	￥1288.00	登錄后可見	- +

規(guī)格

庫存

目錄價

會員專享價

數(shù)量

5 mg

3-5days

￥898.00

登錄后可見

- +

10 mg

3-5days

￥1288.00

登錄后可見

- +

基本信息

英文名稱	Resatorvid \| TAK-242 \| CLI-095
中文名稱	瑞沙托維
CAS號	243984-11-4
分子式	C15H17ClFNO4S
分子量	361.82
外觀	Off-white to yellow solid
儲存條件	Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).

產(chǎn)品詳情

Resatorvid (TAK-242, CLI-095) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α and IL-6 in macrophages with IC50 of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.

相關(guān)文獻

The anticancer effect of the TLR4 inhibition using TAK-242 (resatorvid) either as a single agent or in combination with chemotherapy: A novel therapeutic potential for breast cancer.

PMID: 31535397 DOI: 10.1002/jcb.29397

A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling.

Mol Pharmacol. 2006 Apr;69(4):1288-95.

Resatorvid alleviates experimental inflammatory TMJOA by restraining chondrocyte pyroptosis and synovial inflammation.

PMID: 38031141 PMCID: PMC10685467 DOI: 10.1186/s13075-023-03214-4

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