英文名稱 | GSK2656157 | GSK-2656157 |
---|---|
中文名稱 | GSK2656157 | GSK-2656157 |
CAS號 | 1337532-29-2 |
分子式 | C23H21FN6O |
分子量 | 416.45 |
外觀 | Off-white to light yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | GSK2656157 | GSK-2656157 |
---|---|
中文名稱 | GSK2656157 | GSK-2656157 |
CAS號 | 1337532-29-2 |
分子式 | C23H21FN6O |
分子量 | 416.45 |
外觀 | Off-white to light yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
GSK2656157 is an ATP-competitive and highly selective inhibitor of PERK with IC50 of 0.9 nM in a cell-free assay, 500-fold greater against a panel of 300 kinases. GSK2656157 decreases apoptosis and inhibits excessive autophagy
Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity.
PMID: 23333938 DOI: 10.1158/0008-5472.CAN-12-3109
PMID: 27251848 DOI: 10.1080/08923973.2016.1192191
PMID: 24401334 PMCID: PMC3979916 DOI: 10.4161/cc.27726