英文名稱(chēng) | A-1155463 |
---|---|
中文名稱(chēng) | A-1155463 |
CAS號(hào) | 1235034-55-5 |
分子式 | C35H32FN5O4S2 |
分子量 | 669.79 |
外觀 | Off-white to yellow powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
規(guī)格 | 庫(kù)存 | 目錄價(jià) | 會(huì)員專(zhuān)享價(jià) | 數(shù)量 |
---|---|---|---|---|
1 mg | 3-5days | ¥468.00 | 登錄后可見(jiàn) | |
2 mg | 3-5days | ¥686.00 | 登錄后可見(jiàn) | |
5 mg | 3-5days | ¥968.00 | 登錄后可見(jiàn) | |
10 mg | 3-5days | ¥1366.00 | 登錄后可見(jiàn) | |
25 mg | 3-5days | ¥2366.00 | 登錄后可見(jiàn) | |
50 mg | 3-5days | ¥3688.00 | 登錄后可見(jiàn) |
英文名稱(chēng) | A-1155463 |
---|---|
中文名稱(chēng) | A-1155463 |
CAS號(hào) | 1235034-55-5 |
分子式 | C35H32FN5O4S2 |
分子量 | 669.79 |
外觀 | Off-white to yellow powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
A-1155463, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).
PMID: 25787766 DOI: 10.1126/scitranslmed.aaa4642
PMID: 26134786 PMCID: PMC4487849 DOI: 10.1186/s12943-015-0397-y
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity.
PMID: 25313317 PMCID: PMC4190639 DOI: 10.1021/ml5001867