英文名稱 | Omipalisib | GSK2126458 | GSK458 |
---|---|
中文名稱 | GSK2126458 |
CAS號 | 1086062-66-9 |
分子式 | C25H17F2N5O3S |
分子量 | 505.50 |
外觀 | Off-white to yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Omipalisib | GSK2126458 | GSK458 |
---|---|
中文名稱 | GSK2126458 |
CAS號 | 1086062-66-9 |
分子式 | C25H17F2N5O3S |
分子量 | 505.50 |
外觀 | Off-white to yellow powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Omipalisib (GSK2126458, GSK458) is a highly selective and potent inhibitor of p110α/β/δ/γ, mTORC1/2 with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM in cell-free assays, respectively. Omipalisib induces autophagy.
PMID: 22389471 DOI: 10.1158/1535-7163.MCT-11-0989
Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.
PMID: 24900173 PMCID: PMC4007793 DOI: 10.1021/ml900028r
Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.
PMID: 23899692 PMCID: PMC3800496 DOI: 10.1021/cb400430t