英文名稱 | Siponimod Hemifumarate | BAF-312 Hemifumarate |
---|---|
中文名稱 | 辛波莫德半富馬酸鹽 |
CAS號 | 1234627-85-0 |
分子式 | C29H35F3N2O3·1/2C4H4O4 |
分子量 | 574.63 | 516.61(free) |
英文名稱 | Siponimod Hemifumarate | BAF-312 Hemifumarate |
---|---|
中文名稱 | 辛波莫德半富馬酸鹽 |
CAS號 | 1234627-85-0 |
分子式 | C29H35F3N2O3·1/2C4H4O4 |
分子量 | 574.63 | 516.61(free) |
Siponimod (BAF-312) hemifumarate is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod hemifumarate is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC50s of 0.39, 0.98, >10000, >1000, and 750 nM, respectively). Siponimod hemifumarate can be used for multiple sclerosis (MS) research.
Mechanism of Siponimod: Anti-Inflammatory and Neuroprotective Mode of Action.
PMID: 30621015 PMCID: PMC6356776 DOI: 10.3390/cells8010024
Prospects of siponimod in secondary progressive multiple sclerosis.
PMID: 30038666 PMCID: PMC6050809 DOI: 10.1177/1756286418788013