英文名稱 | Vatalanib Dihydrochloride | Vatalanib 2HCl |
---|---|
中文名稱 | 瓦他拉尼二鹽酸鹽 |
CAS號(hào) | 212141-51-0 |
分子式 | C20H17Cl3N4 |
分子量 | 419.73 |
外觀 | Off-white to pink powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
規(guī)格 | 庫(kù)存 | 目錄價(jià) | 會(huì)員專享價(jià) | 數(shù)量 |
---|---|---|---|---|
20 mg | In-stock | ¥408.00 | 登錄后可見(jiàn) | |
50 mg | In-stock | ¥472.00 | 登錄后可見(jiàn) | |
100 mg | In-stock | ¥678.00 | 登錄后可見(jiàn) |
英文名稱 | Vatalanib Dihydrochloride | Vatalanib 2HCl |
---|---|
中文名稱 | 瓦他拉尼二鹽酸鹽 |
CAS號(hào) | 212141-51-0 |
分子式 | C20H17Cl3N4 |
分子量 | 419.73 |
外觀 | Off-white to pink powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Vatalanib (PTK787 or ZK-222584, cpg-79787 2HCl) 2HCl is a novel, potent and orally bioavailable inhibitor of VEGFR2/KDR with potential anticancer activity. In a cell-free experiment, it inhibits VEGFR2/KDR with an IC50 of 37 nM, is less effective against VEGFR1/Flt-1, and is 18-fold more potent against VEGFR3/Flt-4. With strong anti-proliferative activity in vitro and strong antitumor efficaciousness in vivo, it is an anilinophthalazine analog. The protein kinase domains of VEGFR 1 and 2 are bound by vatalanib, which then inhibits them. The PDGF receptor, c-Kit, and c-Fms are among the related receptor tyrosine kinases that this agent binds to and inhibits.