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鹽酸吉西他濱

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Gemcitabine Hydrochloride | Gemcitabine HCl | LY 188011 hydrochloride | NSC 613327 HCl

產(chǎn)品編號：CL1996A CAS No.：122111-03-9 MDLNo： 分子式：C?H??ClF?N?O? 分子量：299.66
規(guī)格 庫存 目錄價 會員專享價 數(shù)量
250 mg In-stock ￥100.00 登錄后可見
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500 mg In-stock ￥150.00 登錄后可見
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1 g In-stock ￥250.00 登錄后可見
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5 g In-stock ￥400.00 登錄后可見
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基本信息
英文名稱 Gemcitabine Hydrochloride | Gemcitabine HCl | LY 188011 hydrochloride | NSC 613327 HCl
中文名稱鹽酸吉西他濱
CAS號122111-03-9
分子式C?H??ClF?N?O?
分子量299.66
外觀White to off-white powder
儲存條件 4°C, sealed storage, away from moisture and light
產(chǎn)品詳情

Gemcitabine is an active metabolite of the gemcitabine prodrugs NUC-1031   and gemcitabine elaidate   and a prodrug form of gemcitabine di- and triphosphates. Gemcitabine is phosphorylated by intracellular kinases to the intermediate metabolite gemcitabine monophosphate   and the active di- and triphosphate forms.It is cytotoxic to HepG2 hepatocellular carcinoma and A549 non-small cell lung cancer (NSCLC) cells (IC50s = 5.2 and 16 nM, respectively) and inhibits tumor growth in various breast, colon, lung, and pancreatic cancer mouse xenograft models. Gemcitabine (12 mg/kg) sensitizes tumors to antibodies targeting programmed cell death protein 1 (PD-1), decreases the number of tumor-infiltrating regulatory T cells (Tregs), and increases survival in an MC-38 syngeneic mouse model of colon carcinoma.  Formulations containing gemcitabine have been used in the treatment of cancer.

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