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帕比司他

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Panobinostat

產(chǎn)品編號(hào)：CL2002 CAS No.：404950-80-7 MDLNo： 分子式：C21H23N3O2 分子量：349.43
規(guī)格 庫存 目錄價(jià) 會(huì)員專享價(jià) 數(shù)量
10 mg In-stock ￥200.00 登錄后可見
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20 mg In-stock ￥300.00 登錄后可見
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100 mg In-stock ￥1000.00 登錄后可見
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基本信息
英文名稱 Panobinostat
中文名稱帕比司他
CAS號(hào)404950-80-7
分子式C21H23N3O2
分子量349.43
外觀Light brown powder
儲(chǔ)存條件 Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Panobinostat, also known as NVP LBH-589 or LBH-589, is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. On 2/23/2015, it received FDA accelerated approval for use in patients with multiple myeloma who had received at least 2 previous treatments, including bortezomib and an immunomodulatory agent.

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