英文名稱 | Pemetrexed Disodium Heptahydrate | LY231514 disodium heptahydrate |
---|---|
中文名稱 | 培美曲賽二鈉七水合物 |
CAS號 | 357166-29-1 |
分子式 | C20H33N5Na2O13 |
分子量 | 597.48 |
外觀 | White to off-white powder |
儲存條件 | 4°C, sealed storage, away from moisture |
英文名稱 | Pemetrexed Disodium Heptahydrate | LY231514 disodium heptahydrate |
---|---|
中文名稱 | 培美曲賽二鈉七水合物 |
CAS號 | 357166-29-1 |
分子式 | C20H33N5Na2O13 |
分子量 | 597.48 |
外觀 | White to off-white powder |
儲存條件 | 4°C, sealed storage, away from moisture |
Pemetrexed disodium heptahydrate (LY231514; HSDB7316; LY-231514; HSDB-7316; Alimta), the heptahydrated disodium salt of Pemetrexed and a pyrimidine-based antifolate, is an antifolate and antimetabolite anticancer medication. It targets TS, DHFR, and GARFT with Ki values of 1.3 nM, 7.2 nM, and 65 nM, in that order. In a variety of tumor types, including malignant mesothelioma, NSCLC (non-small cell lung carcinoma), carcinomas of the breast, colorectum, uterine cervix, head and neck, and bladder, pemetrexed shows strong antitumor activity.
PMID: 9067281
PMID: 20548032 DOI: 10.4049/jimmunol.0900437