英文名稱 | Nigericin Sodium Salt |
---|---|
中文名稱 | 尼日利亞菌素鈉鹽 |
CAS號(hào) | 28643-80-3 |
分子式 | C40H67NaO11 |
分子量 | 746.94 |
外觀 | White to off-white powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
規(guī)格 | 庫(kù)存 | 目錄價(jià) | 會(huì)員專享價(jià) | 數(shù)量 |
---|---|---|---|---|
5 mg | In-stock | ¥466.00 | 登錄后可見(jiàn) | |
10 mg | In-stock | ¥766.00 | 登錄后可見(jiàn) |
英文名稱 | Nigericin Sodium Salt |
---|---|
中文名稱 | 尼日利亞菌素鈉鹽 |
CAS號(hào) | 28643-80-3 |
分子式 | C40H67NaO11 |
分子量 | 746.94 |
外觀 | White to off-white powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Nigericin is a cationic ionophore that inhibits Golgi function and suppresses growth of gram positive bacteria. It also prevents viral activation and triggers activation of the NALP3 inflammasome. Nigericin acts as an H+, K+, Pb2+ ionophore. Most commonly it is an antiporter of H+ and K+. In the past nigericin was used as an antibiotic active against gram positive bacteria. It inhibits the Golgi functions in Eukaryotic cells. Its ability to induce K+ efflux also makes it a potent activator of the NLRP3 inflammasome.