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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
10 mg	In-stock	￥328.00	登錄后可見	- +
25 mg	In-stock	￥568.00	登錄后可見	- +

基本信息

英文名稱	Everolimus \| RAD-001
中文名稱	依維莫司
CAS號	159351-69-6
分子式	C53H83NO14
分子量	958.22
外觀	White to off-white powder
儲存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

Everolimus, also known as RAD001, is a derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production.

PMID: 20360931 PMCID: PMC2847314 DOI: 10.1593/tlo.09277

PMID: 19223496 DOI: 10.1158/1078-0432.CCR-08-2057

PMID: 29077243 PMCID: PMC5765289 DOI: 10.1111/cas.13431

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CL2331

依維莫司

159351-69-6 98+% In-stock

￥328.00 10 mg

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依維莫司

Everolimus | RAD-001

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