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規(guī)格	庫存	目錄價(jià)	會(huì)員專享價(jià)	數(shù)量
5 mg	3-5days	￥578.00	登錄后可見	- +
10 mg	3-5days	￥1088.00	登錄后可見	- +

規(guī)格

庫存

目錄價(jià)

會(huì)員專享價(jià)

數(shù)量

5 mg

3-5days

￥578.00

登錄后可見

- +

10 mg

3-5days

￥1088.00

登錄后可見

- +

基本信息

英文名稱	Telaglenastat \| CB-839
中文名稱	CB-839
CAS號(hào)	1439399-58-2
分子式	C26H24F3N7O3S
分子量	571.57
外觀	Off-white to yellow powder
儲(chǔ)存條件	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

產(chǎn)品詳情

Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC₅₀s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity.

相關(guān)文獻(xiàn)

The glutaminase inhibitor telaglenastat enhances the antitumor activity of signal transduction inhibitors everolimus and cabozantinib in models of renal cell carcinoma.

PMID: 34731180 PMCID: PMC8565744 DOI: 10.1371/journal.pone.0259241

PMID: 24523301 DOI: 10.1158/1535-7163.MCT-13-0870

PMID: 28671190 PMCID: PMC5500878 DOI: 10.1038/ncomms15965

PMID: 31429768 PMCID: PMC6700828 DOI: 10.1186/s12964-019-0412-9

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CL2411

CB-839

1439399-58-2 98+% 3-5days

￥578.00 5 mg

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CB-839

Telaglenastat | CB-839

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