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規(guī)格	庫存	目錄價	會員專享價	數量
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規(guī)格

庫存

目錄價

會員專享價

數量

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基本信息

英文名稱	SB-743921 free base
中文名稱	SB-743921 free base
CAS號	618430-39-0
分子式	C31H33ClN2O3
分子量	517.06

產品詳情

SB-743921 (SB-921) is an inhibitor of Kinesin Spindle Protein (KSP), a mitotic protein essential for cell cycle control and motility. It functions by selectively targeting rapidly dividing cells and disrupting spindle formation during cell division, leading to G2/M phase arrest and ultimately causing cell death. It also inhibits proliferation and induces apoptosis in diffuse large B-cell lymphoma (DLBCL) cell lines.

相關文獻

A second generation KSP inhibitor, SB-743921, is a highly potent and active therapeutic in preclinical models of cancer.

Kinesin spindle protein inhibitor SB743921 induces mitotic arrest and apoptosis and overcomes imatinib resistance of chronic myeloid leukemia cells.

PMID: 25146433 DOI: 10.3109/10428194.2014.956319

Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.

PMID: 23394180 PMCID: PMC3759169 DOI: 10.1021/jm3014597

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