英文名稱 | BIX-01294 |
---|---|
中文名稱 | BIX-01294 |
CAS號 | 935693-62-2 |
分子式 | C28H38N6O2 |
分子量 | 490.64 |
外觀 | White to off-white powder |
儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4℃, long-term (months to years) storage at -20 ℃. |
英文名稱 | BIX-01294 |
---|---|
中文名稱 | BIX-01294 |
CAS號 | 935693-62-2 |
分子式 | C28H38N6O2 |
分子量 | 490.64 |
外觀 | White to off-white powder |
儲存條件 | Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4℃, long-term (months to years) storage at -20 ℃. |
BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells。