英文名稱 | LY2780301 |
---|---|
中文名稱 | LY2780301 |
CAS號(hào) | 1226801-23-5 |
分子式 | C25H27F4N7O |
分子量 | 517.52 |
英文名稱 | LY2780301 |
---|---|
中文名稱 | LY2780301 |
CAS號(hào) | 1226801-23-5 |
分子式 | C25H27F4N7O |
分子量 | 517.52 |
LY2780301 is a highly selective adenosine triphosphate (ATP)-competitive dual inhibitor of p70S6K and Akt. LY2780301 binds to Akt, inhibiting its activity, which consequently blocks the PI3K/Akt signaling pathway which leads to reduced cell proliferation and the initiation of apoptosis in tumor cells.
PMID: 25902900 DOI: 10.1007/s10637-015-0241-7