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規(guī)格	庫(kù)存	目錄價(jià)	會(huì)員專享價(jià)	數(shù)量
2 mg	3-5days	￥288.00	登錄后可見(jiàn)	- +
5 mg	3-5days	￥498.00	登錄后可見(jiàn)	- +
10 mg	3-5days	￥898.00	登錄后可見(jiàn)	- +
25 mg	3-5days	￥1616.00	登錄后可見(jiàn)	- +

規(guī)格

庫(kù)存

目錄價(jià)

會(huì)員專享價(jià)

數(shù)量

2 mg

3-5days

￥288.00

登錄后可見(jiàn)

- +

5 mg

3-5days

￥498.00

登錄后可見(jiàn)

- +

10 mg

3-5days

￥898.00

登錄后可見(jiàn)

- +

25 mg

3-5days

￥1616.00

登錄后可見(jiàn)

- +

基本信息

英文名稱	CX-5461 \| Pidnarulex
中文名稱	CX-5461
CAS號(hào)	1138549-36-6
分子式	C27H27N7O2S
分子量	513.61
外觀	White to yellow powder
儲(chǔ)存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

CX-5461 is a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX-5461 selectively inhibits rRNA synthesis by Pol I in the nucleolus, but does not inhibit mRNA synthesis by RNA Polymerase II (Pol II) and does not inhibit DNA replication or protein synthesis. Inhibition of Pol I results in nucleolar stress and release of ribosomal proteins (RP) from the nucleolus. The RP bind to Mdm2 and liberate p53 to orchestrate apoptosis in cancer cells. CX-5461 demonstrates a favorable preclinical profile, potently and selectively kills cancer cells, demonstrates robust in vivo efficacy in multiple models, and has demonstrated oral bioavailability in multiple species.

相關(guān)文獻(xiàn)

Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.

PMID: 21159662 DOI: 10.1158/0008-5472.CAN-10-1728

PMID: 22789538 PMCID: PMC3749732 DOI: 10.1016/j.ccr.2012.05.019

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