英文名稱 | Fmoc-6-Ahx-OH/Fmoc-ε-Acp-OH |
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中文名稱 | Fmoc-6-氨基己酸/芴甲氧羰酰基-6-氨基己酸 |
CAS號 | 88574-06-5 |
分子式 | C21H23NO4 |
分子量 | 353.41 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Fmoc-6-Ahx-OH/Fmoc-ε-Acp-OH |
---|---|
中文名稱 | Fmoc-6-氨基己酸/芴甲氧羰酰基-6-氨基己酸 |
CAS號 | 88574-06-5 |
分子式 | C21H23NO4 |
分子量 | 353.41 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Fmoc-6-aminohexanoic acid can be used as a PROTAC linker in the synthesis of PROTACs and other conjugation applications. Fmoc-6-aminohexanoic acid is an alkane chain with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.