Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channel activator. Hyperforin dicyclohexylammonium salt regulates Ca2+ levels by activating Ca2+-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also displays a variety of bioactivities like antidepressant, antitumor, antidementia, and antidiabetic activities. Hyperforin dicyclohexylammonium salt regulates the secretion of IL-17α from γδ T cells and improves Imiquimod induced skin inflammation in psoriasis-like mice.